one of the many changes and problems in a situation or in your life, that you have to deal with 变迁；人生的沉浮；兴衰枯荣 the vicissitudes of family life 家庭生活的变迁
Word Originearly 17th cent. (in the sense ‘alternation’): from French, or from Latin vicissitudo, from vicissim ‘by turns’, from vic- ‘turn, change’.
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