- [usually plural]
a drug, especially a barbiturate, that relaxes you or makes you want to sleep compare upperTopics Social issuesc2镇静药,抑制药(尤指巴比妥类) an experience that makes you feel sad or depressed 令人悲哀(或沮丧)的经历 Not getting the promotion was a real downer. 未得到提升真让人很沮丧。 - on a downer
He's really on a downer (= very depressed). 他确实很郁闷。