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BNC: 20122 COCA: 21864

vicissitude

noun
/vɪˈsɪsɪtjuːd/
/vɪˈsɪsɪtuːd/
[usually plural] (formal)
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  1. one of the many changes and problems in a situation or in your life, that you have to deal with变迁;人生的沉浮;兴衰枯荣
    • the vicissitudes of family life家庭生活的变迁
    Word Originearly 17th cent. (in the sense ‘alternation’): from French, or from Latin vicissitudo, from vicissim ‘by turns’, from vic- ‘turn, change’.

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